compound introduction
20-羧基花生四烯酸（20-COOH-AA）抑制肾脏中的离子运输，非常类似于其母体化合物20-HETE。研究表明20-羧基花生四烯酸会产生被内皮素收缩的猪冠状微血管的血管舒张。另外，20-羧基花生四烯酸结合并激活过氧化物酶体增殖物激活的受体α（PPARα，K | d | = 0.87±0.12 µM）和PPARγ（K | d | = 1.7±0.5 µM）的分离的配体结合域。 20-carboxy arachidonic acid (20-COOH-AA) inhibits ion transport in the kidneys, much like its parent compound 20-HETE. Studies have shown that 20-carboxy arachidonic acid produces vasorelaxation of porcine coronary microvessels constricted with endothelin. Additionally, 20-carboxy arachidonic acid binds to and activates the isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα, K|d|= 0.87 ± 0.12 μM) and PPARγ (K|d|= 1.7 ± 0.5 μM).
