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G6PDi-1

Dangerous Goods

CAS number:2457232-14-1    molecular formula:C14H12N4OS

overview

compound introduction

Information G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD) . G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. Targets G6PD ; NADPH In vitro G6PDi-1 effectively inhibits G6PD. Across a range of cultured cells, G6PDi-1 depletes NADPH most strongly in lymphocytes. In T cells but not macrophages, G6PDi-1 markedly decreases inflammatory cytokine production. In neutrophils, it suppresses respiratory burst. Cell Research(from reference) Cell lines:HepG2 cells, HCT116 cells, T cells Concentrations:25 μM, 50 μM, 75 μM, 100 μM Incubation Time:2 h, 4 h, 6 h

Specs

Chinese alias-
English alias4-(6,7,8,9-tetrahydro-5-oxo-5H-cyclohepta[d]pyrimidin-2-ylamino)thiophene-2-carbonitrile
CAS number2457232-14-1molecular formulaC14H12N4OS
molecular weight284.34 g/molExact mass≥98%
PSA107.000 Ųlogp2.300

numbering system

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physicochemical properties

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Safety information

pictogram:
GHS07
Signal word:
Warning
Hazard Statement:
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。

Production methods and uses

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upstream information

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downstream information

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MSDS

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