Information G6PDi-1 G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD) . G6PDi-1 depletes NADPH and decreases inflammatory cytokine production. Targets G6PD ; NADPH In vitro G6PDi-1 effectively inhibits G6PD. Across a range of cultured cells, G6PDi-1 depletes NADPH most strongly in lymphocytes. In T cells but not macrophages, G6PDi-1 markedly decreases inflammatory cytokine production. In neutrophils, it suppresses respiratory burst. Cell Research(from reference) Cell lines:HepG2 cells, HCT116 cells, T cells Concentrations:25 μM, 50 μM, 75 μM, 100 μM Incubation Time:2 h, 4 h, 6 h
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G6PDi-1
Dangerous GoodsCAS number:2457232-14-1 molecular formula:C14H12N4OS
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Specs
| Chinese alias | - | ||
| English alias | 4-(6,7,8,9-tetrahydro-5-oxo-5H-cyclohepta[d]pyrimidin-2-ylamino)thiophene-2-carbonitrile | ||
| CAS number | 2457232-14-1 | molecular formula | C14H12N4OS |
| molecular weight | 284.34 g/mol | Exact mass | ≥98% |
| PSA | 107.000 Ų | logp | 2.300 |
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physicochemical properties
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Safety information
pictogram:
GHS07
Signal word:
Warning
Hazard Statement:
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures:
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
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