Finerenone

Dangerous Goods

CAS number：1050477-31-0 molecular formula：C21H22N4O3

overview

Specs

numbering system

physicochemical properties

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Production methods and uses

MSDS

overview

compound introduction

Information Finerenone Finerenone (FIN, BAY 94-8862) is a highly selective and orally available nonsteroidal antagonist of mineralocorticoid receptor (MR) with IC50 of 18 nM. Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease. Targets MR (Cell-free assay) 18 nM In vitro Finerenone dose-dependently reduces aldosterone-induced smooth muscle cell (SMC) proliferation and prevents aldosteroneinduced endothelial cell (EC) apoptosis. Finerenone significantly reduces apoptosis of ECs and simultaneously attenuates SMC proliferation, resulting in accelerated endothelial healing and reduced neointima formation of the injured vessels. In vivo Finerenone improves endothelial dysfunction through an enhancement in NO bioavailability and a decrease in superoxide anion levels due to an upregulation in SOD activity. This is associated with an increase in renal SOD activity and a reduction of albuminuria. Cell Research(from reference) Cell lines：Human coronary artery smooth muscle cells (SMC), human umbilical vein endothelial cells (EC) Concentrations：1 nM, 10 nM Incubation Time：24 h

Specs

Chinese alias	-
English alias	AMY9115 \| FINERENONE [INN] \| GTPL8678 \| (S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide \| finerenonum \| Kerendia \| AC-30916 \| BCP24177 \| F53302 \| Finerenone (JAN/USAN/INN) \| FINERENONE [WHO-DD] \| Finerenon
CAS number	1050477-31-0	molecular formula	C21H22N4O3
molecular weight	378.42 g/mol	Exact mass	-
PSA	110.000 Å²	logp	2.400

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Safety information

pictogram：

GHS06 , GHS08

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H373: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医