Information DTHIB DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities. Targets HSF1 (Cell-free assay) 160 nM(Kd) In vitro Direct Targeted HSF1 InhiBitor (DTHIB) physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. In vivo DTHIB potently attenuates tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it causes profound tumor regression. Cell Research(from reference) Cell lines：C4-2, PC-3, BPH-1 cells Concentrations：0.5 μM, 1.0 μM, 2.5 μM, 5 μM Incubation Time：36-hour, 48-hour, 96-hour
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DTHIB
Dangerous GoodsCAS number：897326-30-6 molecular formula：C13H9ClFN3O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 897326-30-6 | molecular formula | C13H9ClFN3O3 |
| molecular weight | 309.68 g/mol | Exact mass | 10mM in DMSO |
| PSA | 87.000 Ų | logp | 3.287 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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