NH2-PEG3-C1-Boc

Dangerous Goods

CAS number：189808-70-6 molecular formula：C12H25NO5

overview

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physicochemical properties

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MSDS

overview

compound introduction

NH2-PEG3-C1-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs. Application： Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. Monodisperse Amino-PEG3-CH2CO2-t-butyl ester (NH2-PEG3-CH2COOtBu) is a heterobifunctional PEG molecule containing an amino (NH2) group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group (t-Boc) can be deprotected under acidic conditions. NH2-PEG3-CH2COOtBu also known as PROTAC Linker 5, can be used as a PROTAC linker, which refers to the alkyl/ether composition.

Specs

Chinese alias	-
English alias	-
CAS number	189808-70-6	molecular formula	C12H25NO5
molecular weight	263.33 g/mol	Exact mass	≥95%
PSA	80.000 Å²	logp	-0.300

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physicochemical properties

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Safety information

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Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。