R-文拉法辛是文拉法辛的光学活性形式。文拉法辛是苯乙胺的衍生物，据报道可通过阻止神经胺如5-羟色胺（5-羟色胺； 5-HT）和去甲肾上腺素（去甲肾上腺素）的突触前再摄取来促进中枢神经系统内的神经传递。还报道了Velanfaxine是多巴胺再摄取的弱抑制剂。|体外研究表明，Venlafaxine对毒蕈碱，组胺能或α-1肾上腺素受体没有明显的活性。据报道，文拉法辛的代谢是通过细胞色素P450（CYP）酶CYP2D6发生的，产生O-去甲基文拉法辛。CYP3A4产生较少的代谢产物N-去甲基文拉法辛。 R-Venlafaxine is an optically active version of Venlafaxine . Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake.|In vitro|studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.
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R-Venlafaxine
CAS number：93413-46-8 molecular formula：C17H27NO2
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Specs
| Chinese alias | - | ||
| English alias | (R)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexan-1-ol | 1-[(1R)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol | (R)-Venlafaxine | R-Venlafaxine | 1-[(1R)-2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol | ||
| CAS number | 93413-46-8 | molecular formula | C17H27NO2 |
| molecular weight | 277.4 g/mol | Exact mass | ≥95% |
| PSA | 32.700 Ų | logp | 2.900 |
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Safety information
RTECS：
GV8872620
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