CAS number：57103-68-1 molecular formula：C28H37ClN2O8
Maytansine is a potent microtubule-targeted compound that inhibits proliferation of cells at mitosis. Antibody-maytansinoid conjugates consisting of maytansinoids (DM1 and DM4) attached to tumor-specific antibodies have shown promising clinical results.The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules.
| Chinese alias | 美登木素 | ||
| English alias | 3-o-De(2-(acetylmethylamino)-1-oxopropyl)maytansine | MFCD28144515 | Ansamitocin P-0Ansamitocin P-0 | (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-6,21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacos | ||
| CAS number | 57103-68-1 | molecular formula | C28H37ClN2O8 |
| molecular weight | 565.05 g/mol | Exact mass | ≥98% |
| PSA | 130.000 Ų | logp | 1.500 |
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