1,2-Dimyristoyl-sn-glycerol

Dangerous Goods

CAS number：60562-16-5 molecular formula：C31H60O5

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overview

compound introduction

具有小极性头基和两个脂肪酸的1，2-二肉豆蔻酰基-sn-甘油（14:0 DG）是大肠埃希菌膜脂质。在生化信号中，二酰基甘油(DAG)充当第二信使信号脂质，并且是磷脂酶C(PLC)（一种膜结合酶）水解磷脂PIP2（磷脂酰肌醇二磷酸酯）的产物，该酶通过相同的反应产生三磷酸肌醇（IP3）。尽管三磷酸肌醇（IP3）扩散到细胞质中，但DAG由于其疏水性而保留在质膜内。IP3刺激钙离子从平滑内质网释放，而DAG是蛋白激酶C(PKC)的生理激活剂。膜中DAG的产生促进了PKC从胞质溶胶到质膜的转运。二酰基甘油模拟了促肿瘤化合物佛波酯的作用。应用： 14:0 DG可用于：用于复溶薄层色谱的干燥脂质；用于RNA递送研究的脂质纳米颗粒中；作为气相色谱-质谱（GC-MS）分析的标准品，用于定量脂质A二酰基甘油。 Product Introduction In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters. 1,2-dimyristoyl-sn-glycerol (14:0 DG) with small polar headgroup and two fatty acid, is an E coli membrane lipid. Application 14:0 DG may be used: in the reconstitution of dry lipids for thin layer chromatography in lipid nanoparticles for RNA delivery studies as a standard in gas chromatography–mass spectrometry (GC-MS) analysis for the quantification of lipid A diacylglycerols

Specs

Chinese alias	DG(14:0/14:0/0:0) \| 1,2-双十四烷酰基-sn-甘油
English alias	AKOS027321143 \| 1,1'-[(1S)-1-(Hydroxymethyl)-1,2-ethanediyl] ditetradecanoate \| B8KC2URW86 \| HY-128468 \| (S)-3-Hydroxypropane-1,2-diylditetradecanoate \| DG(14:0/14:0/0:0) \| (S)-1,2-dimyristin \| OKDZHAQIKCVKFE-UHFFFAOYSA-N \| SCHEMBL593870 \| LMGL02010321 \|
CAS number	60562-16-5	molecular formula	C31H60O5
molecular weight	512.81 g/mol	Exact mass	≥99%
PSA	72.800 Å²	logp	11.900

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Safety information

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P264: 处理后要彻底洗手。 P337+P313: 如仍觉眼刺激：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P332+P313: 如发生皮肤刺激：求医/就诊。

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