CAS number：342808-40-6 molecular formula：C19H15F2NO
EF24 是一种姜黄素类似物，具有更强的抗肿瘤功效和口服生物利用度。在口腔鳞状细胞癌细胞中，EF24 通过抑制 MAPK/ERK 信号通路发挥抗肿瘤作用。EF24 处理可提高活化的 Caspase3 和 Caspase9 的水平，并降低 MEK1 和 ERK 的磷酸化形式的表达。 EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK.
| Chinese alias | (3E,5E)- 3,5-双[(2-氟苯基)亚甲基]-4-哌啶酮 | ||
| English alias | 3,5-Bis[(2-fluorophenyl)methylene]-4-piperidinone | (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one;hydrochloride | EF24 | 3,5-bis((E)-2-fluorobenzylidene)piperidin-4-one hydrochloride | (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinon | ||
| CAS number | 342808-40-6 | molecular formula | C19H15F2NO |
| molecular weight | 311.33 g/mol | Exact mass | - |
| PSA | - | logp | - |
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