Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK , disrupts the binding of FAK and p53. In Vitro Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53 +/+ but not in HCT116 p53 -/- xenografts in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Roslin 2 bromide
Dangerous GoodsCAS number：29574-21-8 molecular formula：C13H19BrN4
overview
compound introduction
Specs
| Chinese alias | 罗斯林 2 溴化物 | ||
| English alias | 1-(Phenylmethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1~3,7~]decane bromide, 1-Benzyl-1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~] decane bromide, 1-Benzyl-3,5,7-triaza-1-azoniaadamantane bromide | 1-benzyl-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane;bromide | ||
| CAS number | 29574-21-8 | molecular formula | C13H19BrN4 |
| molecular weight | 311.22 g/mol | Exact mass | ≥99% |
| PSA | 9.700 Ų | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
WGK Germany：
3
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MSDS
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