iHAP1

Dangerous Goods

CAS number：105925-39-1 molecular formula：C20H14ClNO2S

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information iHAP1 iHAP1 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and potently kills malignant cells. Targets PP2A In vitro Phenothiazine analog iHAP1 activates PP2A-B56ε and potently kills malignant cells. iHAP1 does not inhibit dopamine signaling or cause prohibitive neurologic toxicity. The PP2A complex activated by iHAP1 dephosphorylates the MYBL2 transcription factor on Ser241, causing irreversible arrest of leukemia and other cancer cells in prometaphase. In vivo In preclinical testing against T-ALL xenografts, iHAP1 emerges as a much more promising compound than PPZ, showing improved antitumor activity and lack of toxicity. Cell Research(from reference) Cell lines：HEK293T cells Concentrations：0.5 μM Incubation Time：3 h

Specs

Chinese alias	(2-氯-10H-吩噻嗪-10-基)(4-甲氧基苯基)甲酮
English alias	CUN25391 \| BDBM50483987 \| EX-A4126 \| SCHEMBL22147462 \| Z56843374 \| (2-chlorophenothiazin-10-yl)-(4-methoxyphenyl)methanone \| EN300-6486380 \| (2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone \| Oprea1_789892 \| E75426 \| AKOS001020463 \| HY-136121 \|
CAS number	105925-39-1	molecular formula	C20H14ClNO2S
molecular weight	367.85 g/mol	Exact mass	≥98%
PSA	54.800 Å²	logp	5.200

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水