Gaboxadol hydrochloride (Lu 02-030 hydrochloride) 是一种强效有力的 GABAA receptor 的激动剂和 GABAC receptors 受体拮抗剂 (IC50=25 μM)。Gaboxadol hydrochloride 在亚基 α1β2γ2 显示部分激动剂功效，ED50 值为 143 µM，在 α5 亚基显示出一个完整的受体激动剂功效 (ED50=28-129 µM) 以及在 α4β3δ 亚基也有激动作用 (ED50= 6 µM)。Gaboxadol hydrochloride 是一种非阿片类试剂。 Product description： Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid agent. Application： Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.
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Gaboxadol Hydrochloride
Dangerous GoodsCAS number：85118-33-8 molecular formula：C6H8N2O2 · HCl
overview
compound introduction
Specs
| Chinese alias | 加波沙朵 盐酸盐 | 4,5,6,7-四氢异噁唑[5,4-c]吡啶-3-醇 盐酸盐 | THIP 盐酸盐 | GAB氧杂DOL盐酸盐 | 4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇盐酸盐 | ||
| English alias | THIP hydrochloride | 478RVH3TVD | UNII-478RVH3TVD | SMR000875361 | 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HCL, GABOXADOL-HCL | 85118-33-8 (HCl) | T-101 | SR-01000075651-7 | AKOS024015212 | ISOXAZOLO(5,4-C)PYRIDIN-3(2H)-ONE, 4,5,6,7-TETRAHYDRO-, MO | ||
| CAS number | 85118-33-8 | molecular formula | C6H8N2O2 · HCl |
| molecular weight | 176.6 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 50.400 Ų | logp | - |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H336: 可能引起嗜睡或头晕
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
Found 1 shareMSDS
85118-33-8 | Gaboxadol hydrochloride.pdf
