Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.A competitive cell cycle inhibitor Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner. A competitive cell cycle inhibitor
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Tunicamycin
Dangerous GoodsCAS number：11089-65-9 molecular formula：C39H64N4O16 (for n=10, "Tunicamycin VII")
overview
compound introduction
Specs
| Chinese alias | 链病毒菌素 | ||
| English alias | Tunicamycin fromStreptomycessp. | ||
| CAS number | 11089-65-9 | molecular formula | C39H64N4O16 (for n=10, "Tunicamycin VII") |
| molecular weight | 844.95 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H300: 吞咽致命
Statement of Preventive Measures：
P301+P310: 如误吞咽：立即呼叫急救中心/医生。 P264: 处理后要彻底洗手。
WGK Germany：
3
Personal protective equipment：
Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges
RTECS：
YO7980200
UN Number：
3462
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