BCI ((E)-BCI) hydrochloride is a DUSP6 ( dual specificity phosphatase 6 ) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research In Vitro BCI (100 ng/mL; 24 h) downregulats the expression of DUSP6 in RAW264.7 macrophage cells. BCI (0-1 nM; 24 h) inhibits the expression of IL-1β and IL-6 in lipopolysaccharide- (LPS-) activated macrophages. BCI (0-4 nM; 24 h) decreases ROS production and activates the Nrf2 Pathway in LPS-activated macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: RAW264.7 macrophage cells Concentration: 100 ng/mL Incubation Time: 24 hours Result: Showed DUSP6 protein downregulation. RT-PCRCell Line: RAW264.7 macrophage cells Concentration: 0-1 nM Incubation Time: 24 hours Result: Inhibited the expression of IL-1β and IL-6 mRNA in LPS-activated macrophages. Form:Solid IC50& Target:DUSP6
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BCI hydrochloride
Dangerous GoodsCAS number：95130-23-7 molecular formula：C22H24ClNO
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| Chinese alias | BCI盐酸盐 | ||
| English alias | - | ||
| CAS number | 95130-23-7 | molecular formula | C22H24ClNO |
| molecular weight | 353.89 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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WGK Germany：
3
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