WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor ( IC 50 In Vitro WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture. WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human foreskin fibroblasts ( T. gondii -infected) Concentration: 0-100 nM Incubation Time: 92 h Result: Showed marked inhibition of T. gondii , with an IC 50 value of approximately 50 nM. Cell Cytotoxicity AssayCell Line: Human foreskin fibroblasts Concentration: 0-100 nM Incubation Time: 92 h Result: Lacked of toxicity for fibroblasts. In Vivo WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male mice ( T. gondii -infected) . Dosage: 1.25 mg/kg Administration: Intraperitoneal injection; single daily for 5 days. Result: Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5. Form:Solid IC50& Target:IC50:
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WR99210
Dangerous GoodsCAS number：47326-86-3 molecular formula：C14H18Cl3N5O2
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| Chinese alias | - | ||
| English alias | 6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazinane-2,4-diimine | DTXSID30952947 | WR-99,210 | Aluminum oxide, anhydrous | BRL 6231 (*Monohydrogen chloride*) | 1,6-Dihydro-6,6-dimethyl-1-(3-(2,4,5-trichlorophenoxy)-propoxy)-1,3,5-triazine- | ||
| CAS number | 47326-86-3 | molecular formula | C14H18Cl3N5O2 |
| molecular weight | 394.68 g/mol | Exact mass | ≥98% |
| PSA | 98.500 Ų | logp | 2.800 |
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WGK Germany：
3
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