Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects In Vitro Tetramethylcurcumin (FLLL31; 2.5 and 5 µM; for 24 hours) downregulats STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells. Tetramethylcurcumin inhibits cell viability, cell invasion. Tetramethylcurcumin is a effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:STAT3
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Tetramethylcurcumin
Dangerous GoodsCAS number：52328-97-9 molecular formula：C25H28O6
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| Chinese alias | 四甲基姜黄素 | ||
| English alias | Tetramethylcurcumin | DTXSID70467449 | (1E,6E)-1,7-BIS(3,4-DIMETHOXYPHENYL)-4,4-DIMETHYLHEPTA-1,6-DIENE-3,5-DIONE | CCA32897 | AKOS037515199 | MFCD19443859 | SCHEMBL10054233 | BS-44761 | FLLL31, >=98% (HPLC) | HY-N2521 | FLLL31 | ||
| CAS number | 52328-97-9 | molecular formula | C25H28O6 |
| molecular weight | 424.49 g/mol | Exact mass | ≥99% |
| PSA | 71.100 Ų | logp | 4.800 |
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Hazard Statement：
H413: 可能对水生生物造成长期的有害影响
WGK Germany：
3
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