Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate In Vitro Bufuralol (Ro 3-4787) hydrochloride is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Bufuralol (Ro 3-4787) hydrochloride metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:β adrenergic receptor
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Bufuralol hydrochloride
Dangerous GoodsCAS number：60398-91-6 molecular formula：C16H24ClNO2
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Specs
| Chinese alias | 盐酸布呋洛尔 | ||
| English alias | RO-3-4787 HYDROCHLORIDE | AKOS040744905 | CCRIS 1056 | 59652-29-8 (HCl) | Bufuralol (hydrochloride) | Ro34787 | Ro-34787 | Ro-3-4787 | Ro3-4787 | Ethanol, 2-tert-butylamino-1-(7-ethyl-2-benzofuranyl)-, hydrochloride | Ro 3-4787 hydrochloride | Angium, alp | ||
| CAS number | 60398-91-6 | molecular formula | C16H24ClNO2 |
| molecular weight | 297.82 g/mol | Exact mass | - |
| PSA | 45.400 Ų | logp | - |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H302: 吞食有害
Statement of Preventive Measures：
P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
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