Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter , with IC 50 s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. In Vitro Centanafadine (EB-1020) preferentially inhibits monoamine reuptake in cloned cell lines transfected with human transporters with IC 50 values of 6 and 38 nM, respectively, for NE and DA transporters, Centanafadine has lesser effects on 5-HT transporter as it inhibits the reuptake of 5-HT with an IC 50 value of 83 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo In microdialysis studies, Centanafadine markedly increases NE, and DA concentrations levels in rat prefrontal cortex in vivo with peak increases of 375 and 300%, respectively with the greatest effects on NE, and also increases DA extracellular concentrations in the striatum to 400% of baseline concentrations. Behavioral studies demonstrate that Centanafadine dose-dependently decreases immobility in the mouse tail suspension test of depression to 13% of control levels, and do not stimulate locomotor activity in adult rats in the optimal dose range. Centanafadine dose-dependently inhibits locomotor hyperactivity in juvenile rats lesioned with the neurotoxin 6-hydroxydopamine (100 μg intracisternally) as neonates; a well-established animal model for attention-deficit hyperactivity disorder (ADHD) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 6 nM (human NE), 38 nM (human DA), 83 nM (human serotonin)
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Centanafadine hydrochloride
Dangerous GoodsCAS number：923981-14-0 molecular formula：C15H16ClN
overview
compound introduction
Specs
| Chinese alias | 盐酸西他那法定 | ||
| English alias | EB-1020 HYDROCHLORIDE | Centanafadine-d7 Hydrochloride | E83715 | 3-Azabicyclo(3.1.0)hexane, 1-(2-naphthalenyl)-, hydrochloride (1:1), (1R,5S)- | Centanafadine HCl | Centanafadine (hydrochloride) | (1R,5S)-1-(Naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hyd | ||
| CAS number | 923981-14-0 | molecular formula | C15H16ClN |
| molecular weight | 209.293646 g/mol | Exact mass | ≥99% |
| PSA | 12.000 Ų | logp | - |
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physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS02
Signal word：
Danger
Hazard Statement：
H228: 易燃固体 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H360: 可能损害生育力或未出生的孩子 H252: 大量自加热； 可能着火
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P370+P378: 火灾时：使用干砂、干粉或抗醇泡沫灭火。 P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P240: 地面/粘结容器和接收设备 P241: 使用防爆的[电气/通风/照明/.../]设备。 P391: 收集溢出物 P410: 防止阳光直射 P420: 分开存放。 P235: 保持凉爽 P407: 在堆垛或托盘之间
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MSDS
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