N-Boc-N-bis(PEG2-propargyl) 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。N-Boc-N-bis(PEG2-propargyl) 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。 N-Boc-N-bis(PEG2-propargyl) is a branched PEG derivative with two terminal propargyl groups and a Boc protected amino group. The propargyl groups can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The amino group is reactive with carboxylic acids, activated NHS esters, and carbonyls. The protected amine can be deprotected by acidic conditions. General description N-Boc-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-Boc-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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N-Boc-N-bis(PEG2-propargyl)
CAS number：2100306-86-1 molecular formula：C19H31NO6
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Specs
| Chinese alias | 双(2-(2-(丙-2-炔-1-基氧基)乙氧基)乙基)氨基甲酸叔丁酯 | N-叔丁氧羰基-N-双(二聚乙二醇-炔基) | ||
| English alias | tert-butyl bis(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate | DTXSID801142162 | 4,7,13,16-Tetraoxa-10-azanonadeca-1,18-diynoic acid, 1,1-dimethylethyl ester | 2100306-86-1 | N-Boc-N-bis(PEG2-propargyl) | tert-butyl N,N-bis({2-[2-(prop-2-yn-1-yloxy)ethox | ||
| CAS number | 2100306-86-1 | molecular formula | C19H31NO6 |
| molecular weight | 369.5 g/mol | Exact mass | ≥98% |
| PSA | 66.500 Ų | logp | 0.7 |
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