Protein Function:： Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.
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Recombinant Human TGF-beta RIII Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人TGF-beta RIII蛋白 | 重组人转移生长因子β受体3蛋白 | 重组人类 TGF-β RIII 蛋白 | ||
| English alias | Betaglycan | betaglycan proteoglycan | BGCAN | TBRIII | TGF-beta receptor type 3 | TGF-beta receptor type III | TGF-beta RIII | TGFbetaRIII | TGFBR3 | TGF-bRIII | TGFR-3 | Transforming growth factor beta receptor III | transforming growth factor beta rece | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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