Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Protein Function: The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha ) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed. A soluble form of the IL-6R alpha has been found in the urine of healthy adult humans. This soluble receptor apparently arises from proteolytic cleavage of membrane-bound IL-6R alpha. No naturally-occurring mRNA encoding a truncated form of the IL-6R alpha has been reported. Soluble forms of human and murine IL-6R alpha s have been constructed, however, by insertion of termination codons into the regions of the IL-6R alpha cDNAs encoding the external portions of the receptors and prior to the transmembrane domains. These soluble receptors have been expressed in COS-7 and CHO cells and have been shown to bind to IL-6 in solution and to augment the activity of IL-6 as a result of the binding of the IL-6/IL-6R alpha complex to membrane-bound gp130.
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Recombinant Human IL-6R alpha Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人IL-6R alpha蛋白 | 重组人 IL-6R α 蛋白 | ||
| English alias | CD126 antigen | gp80 | IL 6R | IL 6R 1 | IL 6R alpha | IL-6 receptor alpha chain | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R subunit alpha | IL-6R-alpha | IL-6RA | IL6Q | Il6r | CD126 | IL6RA | IL6RA_HUMAN | IL6RQ | Interleukin 6 receptor | interleuki | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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