结合珠蛋白 来源于人血浆

人血浆中发现的一种急性期血浆蛋白，每100毫升100-300毫克。它能结合血红蛋白，从而防止铁通过肾脏流失。人类的触珠蛋白具有多态性，有三种主要表型：Hp 1-1、Hp 2-1和Hp 2-2。虽然表型分布在种族和地理位置之间可能存在很大差异，但Hp 2-1表型是人类中最常见的表型。结合珠蛋白的血浆浓度在Hp 1-1患者中最高，在Hp 2-1患者中居中，在Hp 2-2患者中最低。Hp 1-1在结合血红蛋白方面最有效，Hp 2-2最无效。这种功能差异可能与癫痫发作的频率和严重程度有关，因为研究人员发现复发性癫痫发作与Hp 2-2表型之间存在相关性。 An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

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