PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation In Vitro PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells not in CXCR3 - T cells. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC 50 of 42±21 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: CXCR3 + T cells and CXCR3 - T cells Concentration: 10, 50, 100, or 200 nM Incubation Time: 30 minutes Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3 + T cells. Did not result in phosphorylation of CCR5 on CXCR3 - T cells. IC50& Target:Human CXCR3
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PS372424 hydrochloride
CAS number：1596362-29-6(DMSO) molecular formula：C33H45ClN6O4
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| Chinese alias | PS372424 盐酸盐 | ||
| English alias | - | ||
| CAS number | 1596362-29-6(DMSO) | molecular formula | C33H45ClN6O4 |
| molecular weight | 625.20 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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