NUCC-390 dihydrochloride is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo . In Vitro NUCC-390 dihydrochloride (10 μM) produces strong (Ca)i response, but this effect can be blocked by the known potent and selective CXCR4 antagonist AMD3100. NUCC-390 dihydrochloride (10 μM; pre-treatment 30 mins) leads to increased levels of pERK, it has the capability of stimulating signaling activity downstream of CXCR4 receptors. NUCC-390 dihydrochloride (10 μM; 2 hours) can induce CXCR4 receptor internalization, and non-treated cells exhibit some diffuse expression of CXCR4-YFP throughout the cytosol and clear expression in the cell membrane in HEK cells. NUCC-390 dihydrochloride (0-1.25 μM; 24 hours) boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: C8161 cells Concentration: 10 μM Incubation Time: Pre-treated 30 mins Result: Increased the level of pERK. Cell Proliferation AssayCell Line: Cerebellar granule neurons (CGNs) Concentration: 0 μM; 0.0625 μM; 0.25 μM; 1.25 μM Incubation Time: 24 hours Result: Stimulated axonal growth via CXCR4. In Vivo NUCC-390 dihydrochloride (hind limb injection; 3.2 mg/kg; twice daily; 3 days) contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following an acute nerve terminal damage by α-LTx in CD-1 mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Six to eight-week-old CD1 miceDosage: 3.2 mg/kg Administration: Hind limb injection; twice daily; 3 days Result: Promoted functional and anatomical recovery of the NMJ. IC50& Target:CXCR4
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NUCC-390 dihydrochloride
CAS number：2749281-71-6(DMSO) molecular formula：C23H35Cl2N5O
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| Chinese alias | NUCC-390 二盐酸盐 | ||
| English alias | - | ||
| CAS number | 2749281-71-6(DMSO) | molecular formula | C23H35Cl2N5O |
| molecular weight | 468.46 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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