N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC 50 s of 51.0 and 30.7 nM for WT BTK and C481S BTK , respectively N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs , such as SJF620 . SJF620 is a potent PROTAC BTK degrader with a DC 50 of 7.9 nM . In Vitro N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC 50 s of 374, 162, and 8.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK)
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N-piperidine Ibrutinib hydrochloride
CAS number：2231747-18-3 molecular formula：C22H23ClN6O
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| Chinese alias | N-哌啶盐酸伊布替尼 | ||
| English alias | - | ||
| CAS number | 2231747-18-3 | molecular formula | C22H23ClN6O |
| molecular weight | 422.91 g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
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