PROTAC HSP90 degrader BP3

PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN -dependent fashion. PROTAC HSP90 degrader BP3 has a certain certain degradation effect on HSP90 protein in MCF-7 cells ( DC 50 =0.99 µM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell In Vitro PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC 50 =0.63 µM in MCF-7 cells, IC 50 =3.53 µM in MDA-MB-231 cells, IC 50 =0.61 µM in 4T1 cells, IC 50 =2.95 µM in MDA-MB-468 cells). PROTAC HSP90 degrader BP3 (2 µM; 6 h) shows degradation activity in the MCF-7 cells (DC 50 =0.99 µM). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MCF-7 cells Concentration: 2 µM Incubation Time: 6 h Result: Showed degradation activity in the MCF-7 cells (DC 50 =0.99 µM). Cell Viability AssayCell Line: 4T1, MDA-MB-468 cells Concentration: 0.01, 1, 100, 10000 µM Incubation Time: 72 h Result: Inhibited the growth of cancer cells (IC 50 =0.61 µM in 4T1 cells, IC 50 =2.95 µM in MDA-MB-468 cells). In Vivo PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6- to 8-week-old female BALB/c mice Dosage: 40 mg/kg Administration: i.p., daily, 12 days Result: Inhibited tumor growth and the tumor inhibition rate was 76.41%. IC50& Target:HSP90 Cereblon

No numbering system information yet

No physical and chemical property information yet

No safety information yet

No production method and use information yet

No upstream information yet

No downstream information yet

No related product information yet