CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC 50 of 520 nM In Vivo CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice) . Dosage: 15 mg/kg. Administration: PO, single dose. Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration. Animal Model: Female Balb/C mice . Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis). Administration: IV and PO Result: Demonstrated moderate clearance (CL 20 mL min −1 kg −1 ) with mean oral bioavailability of 54%. Form:Solid IC50& Target:IC50: 520 nM (BCL6)
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CCT369260
CAS number：2647503-57-7 molecular formula：C24H31ClF2N6O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2647503-57-7 | molecular formula | C24H31ClF2N6O2 |
| molecular weight | 508.99 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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