ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n Appearance:Solid IC50& Target:VHL In Vitro:ARD-266 (Compound 11; 100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (Compound 11; 1-10000 nM; 24 hour Biological Activity:ARD-266 is a highly potent and von Hippel-Lindau E3 ligase-based Androgen Receptor ( AR ) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR -positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC 50 values of 0.2-1 n
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ARD-266
CAS number：unknown molecular formula：C52H59ClN6O7
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C52H59ClN6O7 |
| molecular weight | 915.51 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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