Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader IC50& Target:CDK4 CDK6 In Vitro:Abemaciclib metabolite M18 hydrochloride exhibits T 1/2 of 43.1 hr in plasma in healthy subjects. CDK4/6 inhibitors’ chief mechanism of action is inhibition of retinoblastoma (RB) protein phosphorylation and thus the induction of cell cycle arrest, C In Vivo:CDK4/6 inhibitors results T-cell persistence and immunologic memory increasing in mice receiving tumor-specific CD8 + T cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib ( HY-16297A ), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader
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Abemaciclib metabolite M18 hydrochloride
CAS number：unknown molecular formula：C25H29ClF2N8O
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| Chinese alias | Abemaciclib 代谢物 M18 盐酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C25H29ClF2N8O |
| molecular weight | 531 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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