compound introduction
WYE-687 dihydrochloride 是一种 ATP 竞争性的 mTOR 抑制剂，IC50 为 7 nM。WYE-687 dihydrochloride 抑制 mTORC1 和 mTORC2 活化。WYE-687 也抑制 PI3Kα 和 PI3Kγ，IC50 分别为 81 nM 和 3.11 μM。
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WYE 687 dihydrochloride
CAS number：1702364-87-1 molecular formula：C28H34Cl2N8O3
overview
Specs
| Chinese alias | N-[4-[4-(4-吗啉基)-1-[1-(3-吡啶基甲基)-4-哌啶基] -1H-吡唑并[3,4-d]嘧啶-6-基]苯基]-氨基甲酸酯酸性甲酯二盐酸盐 | ||
| English alias | N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride | WYE-687 dihydrochloride | ||
| CAS number | 1702364-87-1 | molecular formula | C28H34Cl2N8O3 |
| molecular weight | 601.53 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | - | logp | - |
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