compound introduction
Nexinhib20 是一种特异性的 Rab27a-JFC1 相互作用抑制剂，计算出的IC50 为 2.6 μM。Nexinhib20 显著抑制超氧阴离子的产生。Nexinhib20 有效地减少中性粒细胞在 fMLP、GM-CSF 或两者刺激下的嗜氮颗粒的胞吐。Nexinhib20 具有显著的抗炎活性。 Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity.
