compound introduction
GNE 2861 是 PAK 的抑制剂，对 group II 具有选择性。GNE 2861 抑制 PAK4，PAK5 和 PAK6 的 IC50 值分别为7.5，36和126 nM。
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GNE 2861
CAS number：1394121-05-1 molecular formula：C22H26N6O2
overview
Specs
| Chinese alias | 1-[2-[1-(2-氨基-4-嘧啶基)-2-[(2-甲氧基乙基)氨基] -1H-苯并咪唑-6-基]乙炔基]环己醇 | ||
| English alias | PAK-IN-1 | 1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol | ||
| CAS number | 1394121-05-1 | molecular formula | C22H26N6O2 |
| molecular weight | 406.48 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 111.000 Ų | logp | 2.6 |
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