CAS number：1057394-06-5 molecular formula：C21H21F3N4O
AL 8697 是一种特异性的，具有活性的 p38α MAPK 抑制剂，IC50 为 6 nM。与 p38β (IC50=82 nM) 相比，AL 8697 对 p38α 的抑制作用强 14 倍，对 p38α 的选择性比其他 91 种激酶高 300 倍。具有抗炎活性。 Product description AL 8697 is a specific and active p38α MAPK inhibitor with an IC50 of 6 nM. AL 8697 displays 14-fold greater inhibition of p38α compared to p38β (IC50=82 nM), and 300-fold selectivity for p38α over a panel of 91 kinases. Anti-inflammatory activity.
| Chinese alias | N-环丙基-3-[3-(1,1-二甲基乙基)-6,8-二氟-1,2,4-三唑[4,3-a]吡啶-7-基] -5-氟-4-甲基苯甲酰胺 | ||
| English alias | N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide | 3-(3-(tert-butyl)-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide | ||
| CAS number | 1057394-06-5 | molecular formula | C21H21F3N4O |
| molecular weight | 402.41 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 59.300 Ų | logp | 5 |
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