compound introduction
(Rac)-Calpain Inhibitor XII 是可逆的，选择性的钙蛋白酶 I (calpain I; μ-calpain) 抑制剂，Ki 值为 19 nM。(Rac)-Calpain Inhibitor XII 对钙蛋白酶 II (calpain II; m-calpain; Ki=120 nM) 和组织蛋白酶 B (cathepsin B; Ki=750 nM) 具有较低的亲和力。(Rac)-Calpain Inhibitor XII 有潜力用于研究钙蛋白酶在多种过程中的作用，包括嗜中性粒细胞趋化性，神经元信号传导和心脏对损伤的反应。 Calpain Inhibitor XII is a cell-permeable, potent, selective, reversible, and active-site-directed inhibitor of calpain-1 (K|i|= 19 nM). Calpain Inhibitor XII has been shown to inhibit calpain-2 (K|i|= 120 nM) and human cathepsin B (K|i|= 750 nM) only at higher concentrations. Calpain Inhibitor XII has been reported to induce neutrophile polarization and chemokinesis.
