Aβ/tau aggregation-IN-1

Aβ/tau aggregation-IN-1 is a potent Aβ 1-42 β-sheets formation and tau aggregation inhibitor. The K D values of Aβ/tau aggregation-IN-1 with Aβ 1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier In Vitro Aβ/tau aggregation-IN-1 (1 μM; 24 hours; HEK-293 T cells) significantly declines the tau aggregation foci. Aβ/tau aggregation-IN-1 with N-methylation of the quinolone ring effectively inhibits Aβ 1-42 aggregation by 84.7%–99.5% and tau aggregation by 71.2%–101.8%. Aβ/tau aggregation-IN-1 inhibits self-induced Aβ 1-42 aggregation by inhibiting the formation of β-sheets. Aβ/tau aggregation-IN-1 shows certain binding abilities with Aβ 1-42 and tau. The K D value of Aβ/tau aggregation-IN-1 with Aβ 1-42 is 160 μM. The K D value of Aβ/tau aggregation-IN-1 with tau is 337 μM. Aβ/tau aggregation-IN-1 interacts with Aβ 1-42 and tau through noncovalent interactions. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: HEK-293 T cells Concentration: 1 μM Incubation Time: 24 hours Result: Significantly declined the tau aggregation foci. Form:Solid IC50& Target:Kd: 160 μM (Aβ1-42),Kd: 337 μM (tau)

No numbering system information yet

No physical and chemical property information yet

No safety information yet

No production method and use information yet

No upstream information yet

No downstream information yet

No related product information yet