compound introduction
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB 4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB 4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB 4 receptor on isolated human neutrophil cell membranes with K i values of 1.7 nM In Vitro BIIL-260 hydrochloride potently inhibits LTB 4 -induced intracellular Ca 2+ release in human neutrophils with IC 50 value of 0.82 nM MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:Ki: 1.7 nM (LTB 4 receptor)
