AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a K i of 43 nM and an IC 50 of 300 nM for KIFC1. In Vitro AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC 50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:HSET/KIFC1|300 nM (IC|50|)|HSET/KIFC1|43 nM (Ki)
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AZ82
CAS number：1449578-65-7 molecular formula：C28H31F3N4O3S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1449578-65-7 | molecular formula | C28H31F3N4O3S |
| molecular weight | 560.64 g/mol | Exact mass | ≥99% |
| PSA | 121.000 Ų | logp | 5.800 |
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