KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1) , is also a selective and potent a-site inhibitor of PDIA1 with an IC 50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family In Vitro KSC-34 is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins. KSC-34 contains a (4-phenylbutyl)methylamine diversity element for optimized binding to the active site of the a domain of PDIA1 with a chloroacetamide electrophile for covalent modification of C53 on PDIA1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 3.5 μM (a active site of PDIA1), 104.5 μM (a′ active site of PDIA1)
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KSC-34
CAS number：2226201-97-2 molecular formula：C21H28ClN7O
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2226201-97-2 | molecular formula | C21H28ClN7O |
| molecular weight | 429.95 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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