Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease In Vitro Ibiglustat (SAR402671) (1 μM, 15 days) L-Malic acid treated Fabry disease (FD) cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat L-Malic acid can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Glucosylceramide synthase
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Ibiglustat (L-Malic acid)
CAS number：1629063-78-0 molecular formula：C24H30FN3O7S
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| Chinese alias | 伊比鲁司特(L-苹果酸) | ||
| English alias | (2S)-2-HYDROXYBUTANEDIOIC ACID - (3S)-1- AZABICYCLO(2.2.2)OCT-3-YL (2-(2-(4-FLUOROPHENYL)-1,3-THIAZOL-4-YL)PROPAN-2-YL) CARBAMATE | Venglustat L-malate | Venglustat malate (USAN) | SAR-402671 L-MALATE | Venglustat malate | 94855LQZ8D | Genz-682452-AU | Ib | ||
| CAS number | 1629063-78-0 | molecular formula | C24H30FN3O7S |
| molecular weight | 523.57 g/mol | Exact mass | ≥98% |
| PSA | 178.000 Ų | logp | - |
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