CAS number：125313-92-0 molecular formula：C22H16N4O4
MKC-1 (Ro-31-7453) 是一种口服有效的细胞周期抑制剂，具有广泛的抗肿瘤活性。MKC-1 抑制 Akt/mTOR 通路。通过结合一系列不同的细胞蛋白，包括微管蛋白 (tubulin) 和导入蛋白 β (importin β) 家族成员，MKC-1 阻止细胞有丝分裂并诱导细胞凋亡 (apoptosis)。 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
| Chinese alias | - | ||
| English alias | R 440 | DNZ11VPY7Q | AKOS030228212 | BDBM2622 | Ro-31-7453 | Piromelatine | NEU-P-11 | Piromelatine [INN] | NEU-P11 | ||
| CAS number | 125313-92-0 | molecular formula | C22H16N4O4 |
| molecular weight | 400.39 g/mol | Exact mass | ≥98% |
| PSA | 102.000 Ų | logp | 2.6 |
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