MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K d of 2.0 μM and an IC 50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity In Vitro MLS000544460 does not bind Eya3 phosphatase (ED). MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells. When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg 2+ , it binds MLS000544460 with a higher affinity (K d =0.80 μM), indicating that this class of compounds does not require Mg 2+ for its interaction with the Eya2 ED. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Kd: 2.0 μM (Eya2 phosphatase), IC50: 4 μM (Eya2 phosphatase)
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MLS000544460
CAS number：352336-36-8 molecular formula：C17H12FN3O2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 352336-36-8 | molecular formula | C17H12FN3O2S |
| molecular weight | 341.36 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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