JTT 551 is selective a protein tyrosine phosphatase 1B ( PTP1B ) inhibitor, with K i s of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. In Vitro JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K i s of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with K i s of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.22 μM (PTP1B), 9.3 μM (TCPTP)
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JTT 551
CAS number：776309-04-7 molecular formula：C34H43N3O3S2
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Specs
| Chinese alias | - | ||
| English alias | 2-(((5-(tert-Butyl)thiazol-2-yl)methyl)((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)amino)acetic acid | GLYCINE, N-((5-(1,1-DIMETHYLETHYL)-2-THIAZOLYL)METHYL)-N-((4-(4-((4-(1-PROPYLBUTYL)PHENOXY)METHYL)PHENYL)-2-THIAZOLYL)METHYL)- | H | ||
| CAS number | 776309-04-7 | molecular formula | C34H43N3O3S2 |
| molecular weight | 605.85 g/mol | Exact mass | ≥99% |
| PSA | 132.000 Ų | logp | 6.800 |
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