MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor( IC 50 =6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13 , MMP-1 and MMP-9 with IC 50 s of 1.8 μM,10 μM, and 13 μM, respectively In Vitro MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM. MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:MMP-2 6.6 μM (IC 50 ) MMP-13 1.8 μM (IC 50 ) MMP-1 10 μM (IC 50 ) MMP-9 13 μM (IC 50 )
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MMPI-1154
CAS number：1382722-47-5 molecular formula：C26H24FN3O3
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1382722-47-5 | molecular formula | C26H24FN3O3 |
| molecular weight | 445.49 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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