Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine proagent of S516 and a vascular disrupting agent (VDA). Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors In Vivo Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells Dosage: 5 mg/kg Administration: Intraperitoneal injection; administered on days 2, 6, 10, and 14 Result: Had shown marked antitumor efficacy in various human tumor xenograft models. Form:Solid IC50& Target:β-tubulin polymerization
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Valecobulin hydrochloride
CAS number：1240321-53-2 molecular formula：C26H29ClN6O5S
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| Chinese alias | 盐酸伐可布林 | ||
| English alias | 1240321-53-2 | EX-A3326 | CKD-516 HCl | AC-35651 | Valecobulin hydrochloride | Valecobulin (hydrochloride) | HY-13598A | (2S)-2-amino-3-methyl-N-[4-[3-(1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol-2-yl]butanamide;hydrochloride | AKOS | ||
| CAS number | 1240321-53-2 | molecular formula | C26H29ClN6O5S |
| molecular weight | 573.06 g/mol | Exact mass | ≥98% |
| PSA | 172.000 Ų | logp | - |
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