p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC 50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability. In Vivo p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t 1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C max of 5.3 μM for po in male wistar rats . p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED 50 of 0.5 mg/kg . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male wistar rats Dosage: 10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis) Administration: Po and iv Result: Had a t 1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C max of 5.3 μM for po. Form:Solid IC50& Target:p38 MAPK 68 nM (IC 50 )
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p38 MAPK-IN-1
CAS number：1006378-90-0 molecular formula：C21H15F2N2O
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| Chinese alias | p38 丝裂原蛋白激酶 | ||
| English alias | - | ||
| CAS number | 1006378-90-0 | molecular formula | C21H15F2N2O |
| molecular weight | 349.35 g/mol | Exact mass | ≥99% |
| PSA | 38.400 Ų | logp | 4 |
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