Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis ( Mtb ) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb . Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC 50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium In Vivo Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability . Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse . PO (50 mg/kg) IV (5 mg/kg) C max (ng/mL) 1333 1241 T max (h) 0.83 T 1/2 (h) 0.51 0.33 AUC 0-t (ng/mL·h) 2197 1667 AUC 0-∞ (ng/mL·h) 2198 1672 MRT 0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mouse Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability. Form:Solid IC50& Target:MIC: 0.452-0.499 μg/mL ( Mtb )
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Mtb ATP synthase-IN-1
CAS number：2642394-38-3 molecular formula：C17H13N3O4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2642394-38-3 | molecular formula | C17H13N3O4 |
| molecular weight | 323.30 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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