GPR40 agonist 4 is a potent free fatty acid receptor 1 ( FFA1/ GPR40 ) agonist with a pEC 50 of 7.54. In Vitro GPR40 agonist 4 tends to have a low risk of activating caspase-3/7. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC 0-120min ) and blood insulin (AUC 0-120min ) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:pEC 50 : 7.54 (FFA1/GPR40)
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GPR40 agonist 4
CAS number：2102196-57-4 molecular formula：C21H17ClO5S
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| Chinese alias | GPR40 激动剂 4 | ||
| English alias | - | ||
| CAS number | 2102196-57-4 | molecular formula | C21H17ClO5S |
| molecular weight | 416.87 g/mol | Exact mass | ≥98% |
| PSA | 89.100 Ų | logp | 4.500 |
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