UMB298 is a potent and selective CBP/P300 bromodomain inhibitor In Vitro UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MOLM13 and MM cells Concentration: 0.01~10 μM Incubation Time: 50 days Result: Inhibited cells growth. Western Blot AnalysisCell Line: MOLM13 cells Concentration: 1~10 μM Incubation Time: 2 hours Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. RT-PCRCell Line: MOLM13 cells Concentration: 3 μM Incubation Time: 2 hours Result: Down-regulated MYC expression. Form:Solid IC50& Target:BRD4 5193 nM (IC 50 )
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UMB298
CAS number：2266569-73-5 molecular formula：C27H31ClN4O2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 2266569-73-5 | molecular formula | C27H31ClN4O2 |
| molecular weight | 479.01 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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