IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis In Vitro IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:RAD51
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IBR2
CAS number：313526-24-8(DMSO) molecular formula：C24H20N2O2S
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 313526-24-8(DMSO) | molecular formula | C24H20N2O2S |
| molecular weight | 400.5 g/mol | Exact mass | 10mM in DMSO |
| PSA | - | logp | - |
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