Neuropeptide Y (13-36), amide, human

Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y 2 receptor agonist. In Vivo Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED 50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat . Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into naïve mice impairs social novelty preference, but not sociability, and this effect is inhibited by the NPY Y 2 receptor antagonist BIIE 0246. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ICR mice (age 4-7 weeks)Dosage: 50 ng/mouse Administration: Intracerebroventricular injection Result: Significantly decreased interaction time with the new stranger mouse in session 3 that NPY 13-36. Form:Solid

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